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Updated: Aug 12, 2026

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells
15:29

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[A 14-year-old Syrian refugee with neurobrucellosis]

M S W Quaak1, H H J Bavelaar, J Berkhout

  • 1Radboudumc Amalia Kinderziekenhuis, afd. Kindergeneeskunde, Nijmegen.

Nederlands Tijdschrift Voor Geneeskunde
|November 11, 2017
PubMed
Abstract

Insights

Neurobrucellosis, a rare complication of brucellosis, requires vigilance in non-endemic areas. Prompt diagnosis and management, including cerebrospinal fluid analysis and neurosurgical intervention, are crucial for patient recovery.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • Brucellosis is a zoonotic bacterial infection endemic in the Middle East.
  • Neurobrucellosis is a rare but serious complication.
  • Increased global migration necessitates awareness in non-endemic regions like the Netherlands.

Observation:

  • A 14-year-old migrant presented with severe neurological symptoms including headache, vomiting, and weight loss.
  • Brucella melitensis was detected in cerebrospinal fluid, indicating neurobrucellosis.
  • The patient developed hydrocephalus, requiring external ventricular drainage.

Findings:

  • Neurological deterioration occurred despite initial antibiotic therapy.
  • Antibiotic treatment for brucellosis can precipitate a Jarisch-Herxheimer-like reaction.
  • Complete recovery was achieved after 8 months of antibiotics and CSF management.

Implications:

  • Highlights the importance of considering imported infectious diseases in migrant populations.
  • Emphasizes the need for thorough medical history, including origin-specific epidemiology.
  • Underscores the critical role of timely diagnosis and multidisciplinary management in neurobrucellosis.

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