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Effects of a Grapevine Shoot Extract Containing Resveratrol and Resveratrol Oligomers on Intestinal Adenoma
Michael T Empl1, Hong Cai2, Shan Wang1
1Institute for Food Toxicology, University of Veterinary Medicine Hannover, Hannover, Germany.
Scope:
Evidence suggests that the dietary consumption of plant extracts containing polyphenols might help prevent the onset of cancers of the gastrointestinal tract. In the present study, the chemopreventive and antiproliferative efficacy of a grapevine shoot extract (Vineatrol®30) containing resveratrol and resveratrol oligomers is investigated in vivo and in vitro.
Methods And Results:
The in vivo study is performed using ApcMin mice on a high-fat diet, which represents a model of human adenomatous polyposis, while the potential of the extract as well as some of its isolated constituents to inhibit intestinal adenoma cell proliferation in vitro is investigated using APC10.1 cells derived from an ApcMin mouse. Vineatrol®30 at a low (2.3 mg kg-1 diet) or high dose (476 mg kg-1 diet) reduces the adenoma number in male and adenoma volume in female animals. Furthermore, Vineatrol®30 as well as resveratrol and two resveratrol tetramers compromise the expansion of APC10.1 cells by reducing cell number, inducing cell cycle arrest, cellular senescence, and apoptosis. However, except for the extract, none of the isolated resveratrol oligomers is more efficacious than resveratrol in these cells.
Conclusion:
Vineatrol®30 may merit further investigation as a potential dietary gastrointestinal cancer chemopreventive agent in humans.
Insights
Grapevine shoot extract (Vineatrol®30) containing resveratrol shows promise in preventing gastrointestinal cancers. This dietary polyphenol agent reduced adenomas in mice and inhibited cancer cell proliferation in vitro.
Area of Science:
- Dietary chemoprevention
- Gastrointestinal cancer research
- Polyphenol efficacy
Background:
- Plant-derived polyphenols, including resveratrol, are investigated for their potential to prevent gastrointestinal cancers.
- Grapevine extracts are a rich source of resveratrol and its oligomers, suggesting potential chemopreventive properties.
Purpose of the Study:
- To evaluate the chemopreventive and antiproliferative effects of a grapevine shoot extract (Vineatrol®30) containing resveratrol and its oligomers.
- To assess the efficacy of Vineatrol®30 in an in vivo model of intestinal polyposis and in vitro cancer cell lines.
Main Methods:
- In vivo study: ApcMin mice on a high-fat diet were treated with low or high doses of Vineatrol®30.
- In vitro study: APC10.1 intestinal adenoma cells were treated with Vineatrol®30, resveratrol, and isolated resveratrol oligomers.
- Assessed outcomes included adenoma formation, cell proliferation, cell cycle arrest, senescence, and apoptosis.
Main Results:
- Vineatrol®30 significantly reduced adenoma number in male and adenoma volume in female ApcMin mice.
- The extract and its constituents, including resveratrol and specific tetramers, inhibited APC10.1 cell proliferation.
- Resveratrol and isolated oligomers induced cell cycle arrest, senescence, and apoptosis in cancer cells.
Conclusions:
- Vineatrol®30 demonstrates significant chemopreventive and antiproliferative effects against gastrointestinal cancer models.
- The extract shows potential as a dietary agent for preventing gastrointestinal cancers in humans.
- Further investigation into Vineatrol®30 as a human chemopreventive agent is warranted.
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