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Updated: Feb 19, 2026
Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
Published on: October 12, 2016
Bone cyst formation after ankle arthroplasty may be caused by stress shielding. A numerical simulation of the strain
Hazibullah Waizy1, Bernd-Arno Behrens2, Kerstin Radtke3
1Clinic for Foot and Ankle Surgery, Hessing Foundation, Hessingstr. 17, 86199 Augsburg, Germany; Laboratory for Biomechanics and Biomaterials, Department of Orthopaedics, Hannover Medical School, Anna-von-Borries-Str. 1-7, 30625 Hannover, Germany.
Background:
The history of total ankle arthroplasty (TAA) has different evolution steps to improve the outcome. The third generation implants show an overall 8-year survival rate up to 93%. The main reported reason for early failure of TAA is aseptic loosening, cyst formation is also frequently reported. The aim of the present study is to use the finite element (FE) method to analyze the adaptive bone remodeling processes, including cyst formation after TAA.
Methods:
Bone characteristics applied to the model corresponded to information obtained from computed tomography. Finite element models for the tibia and the talus were developed and implant components were virtually implanted.
Results:
The calculated total bone loss is 2% in the tibia and 17% in the talus. Cysts and areas of increased bone density were detectable dependent on prosthesis design in the tibia and talus.
Conclusion:
Our FE simulation provides a theoretical explanation for cyst formation and increasing bone density depending on implant design. However, cysts are not mono-causal, histo-chemical reactions should also be considered. Further clinical studies are necessary to evaluate the relevance of cyst formation and therapeutic strategies.
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