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Elevated circulating endothelial-specific microRNAs in migraine patients: A pilot study.

Chun-Yu Cheng1,2,3, Shih-Pin Chen1,2,4,5,6, Yi-Chu Liao1,2

  • 11 Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

Cephalalgia : an International Journal of Headache
|November 12, 2017
PubMed
Summary

Circulating microRNAs (miRs) linked to vascular health are elevated in migraine patients, potentially correlating with syncope frequency. This finding suggests miRs may play a role in migraine-associated vascular dysfunction.

Keywords:
Migraineendothelial dysfunctionmicroRNAssyncope

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Area of Science:

  • Vascular Biology
  • Molecular Medicine
  • Neurology

Background:

  • Growing evidence links vascular dysfunction to migraine pathogenesis.
  • MicroRNAs (miRs) are key regulators of endothelial cell function.
  • Investigating circulating miRs offers insights into vascular health in migraine.

Purpose of the Study:

  • To explore alterations in circulating endothelial function-related miRs in migraine patients.
  • To assess potential associations between miR levels and migraine characteristics, including syncope.

Main Methods:

  • Quantified levels of four endothelial miRs (miR-155, miR-126, miR-21, Let-7g) in 30 migraine patients and 30 controls.
  • Expressed miR levels as fold changes relative to controls.
  • Analyzed associations with headache features and syncope comorbidity.

Main Results:

  • Migraine patients showed significantly higher levels of miR-155, miR-126, and Let-7g compared to controls.
  • Elevated miR-155 and miR-126 levels correlated with increased syncope frequency in migraine patients.
  • Migraine with aura showed a trend towards higher miR levels, though not statistically significant.

Conclusions:

  • Circulating endothelial-specific miRs are elevated in migraine patients in this pilot study.
  • These elevated miRs may be linked to vascular endothelial dysfunction in migraine.
  • MiR levels might be associated with syncope comorbidity in migraineurs.