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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Updated: Feb 19, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
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Very early onset inflammatory bowel disease.

Christopher J Moran1

  • 1Harvard Medical School, Department of Pediatrics, 175 Cambridge St, Suite 567, Boston, MA 02114.

Seminars in Pediatric Surgery
|November 12, 2017
PubMed
Summary

Very early onset inflammatory bowel disease (VEO-IBD) in children can be linked to genetic immune defects. While many VEO-IBD cases mirror adult disease, early presentation necessitates prolonged immunosuppression, increasing risks.

Keywords:
ImmunodeficiencyVery early onset IBD

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Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Genetics

Background:

  • Very early onset inflammatory bowel disease (VEO-IBD) is a distinct and increasing group of pediatric IBD patients.
  • Some VEO-IBD cases are associated with immunodeficiency and genetic mutations affecting immune pathways.
  • Identifying Mendelian causes is crucial for VEO-IBD with extra-intestinal autoimmunity or atypical histopathology.

Purpose of the Study:

  • To analyze the characteristics and implications of VEO-IBD.
  • To highlight the role of genetic factors and immunodeficiency in VEO-IBD.
  • To discuss the long-term risks associated with early-onset disease.

Main Methods:

  • Review of existing literature on VEO-IBD.
  • Analysis of genetic and immunological findings in VEO-IBD patients.
  • Comparison of disease course in VEO-IBD versus adult IBD.

Main Results:

  • A subset of VEO-IBD patients presents with immunodeficiency and genetic mutations.
  • The majority of VEO-IBD patients exhibit disease courses comparable to adult IBD.
  • Early presentation often mandates extended immunosuppression.

Conclusions:

  • VEO-IBD encompasses diverse presentations, including genetic immune disorders.
  • While not all VEO-IBD is aggressive, early onset increases long-term risks.
  • Prolonged immunosuppression in VEO-IBD elevates risks for infections and cancer.