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Functionally-Relevant Morphological Profiling: A Tool to Assess Cellular Heterogeneity.

Ross A Marklein1, Johnny Lam1, Murat Guvendiren2

  • 1U.S. Food and Drug Administration, Center for Biologics Research and Evaluation, Silver Spring, MD 20993, USA.

Trends in Biotechnology
|November 12, 2017
PubMed
Summary
This summary is machine-generated.

Cellular therapies face challenges due to cell function variability. Functionally-relevant morphological profiling offers a new approach to understand and address this heterogeneity, improving therapeutic development.

Keywords:
biomaterialscellular quality attributeshigh-content imaginghigh-throughput screeningmorphology

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Area of Science:

  • Cell Biology
  • Biotechnology
  • Drug Discovery

Background:

  • Cellular therapies are hindered by functional heterogeneity, impacting clinical translation.
  • Existing methods for assessing cell quality and behavior inadequately address heterogeneity.
  • Morphological profiling is increasingly used to understand cell function and heterogeneity.

Purpose of the Study:

  • Introduce the emerging field of functionally-relevant morphological profiling.
  • Highlight its potential to improve understanding of cellular heterogeneity.
  • Demonstrate its applications in discovering quality attributes, optimizing manufacturing, and drug screening.

Main Methods:

  • Review of current limitations in cell quality assessment.
  • Discussion of the relationship between cell morphology and function.
  • Introduction of functionally-relevant morphological profiling as a novel approach.

Main Results:

  • Functionally-relevant morphological profiling can uncover novel quality attributes.
  • This approach aids in optimizing manufacturing processes for cellular therapies.
  • It shows promise for screening drugs and biomaterials relevant to cell function.

Conclusions:

  • Functionally-relevant morphological profiling is a promising field for addressing cellular heterogeneity.
  • This technique can enhance the development and translation of cellular therapies.
  • It offers a powerful tool for quality control and therapeutic innovation.