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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Published on: December 31, 2013

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The role of TRPV4 in fibrosis

Lei Zhan1, Jun Li2

  • 1Department of gynecology and obstetrics, The Second Affiliated Hospital of Anhui Medical University, Furong Road, Hefei, 230601, China.

Gene
|November 12, 2017
PubMed

Insights

Transient Receptor Potential Vanilloid 4 (TRPV4) channels regulate fibrosis by influencing extracellular matrix accumulation. Understanding TRPV4

Area of Science:

  • Physiology
  • Pathology
  • Molecular Biology

Background:

  • Transient Receptor Potential Vanilloid 4 (TRPV4) channels are implicated in various pathological processes.
  • Fibrosis is characterized by excessive extracellular matrix (ECM) deposition in tissues.
  • TRPV4's role in fibrotic diseases like myocardial, cystic, pulmonary, hepatic, and pancreatic fibrosis is increasingly recognized.

Purpose of the Study:

  • To review current knowledge on TRPV4.
  • To elucidate the mechanisms linking TRPV4 to fibrosis.
  • To discuss TRPV4 as a therapeutic target for fibrotic diseases.

Main Methods:

  • Literature review of studies on TRPV4 and fibrosis.
  • Analysis of signaling pathways involving TRPV4 in fibrotic conditions.

Main Results:

  • TRPV4 plays a significant role in the progression of diverse fibrotic diseases.
  • Evidence suggests TRPV4 influences ECM accumulation.
  • Specific signaling pathways mediating TRPV4's fibrotic effects are being identified.

Conclusions:

  • TRPV4 is a key regulator in multiple fibrotic conditions.
  • Further research into TRPV4 mechanisms is needed.
  • TRPV4 presents a promising therapeutic target for treating fibrosis.
Keywords:
FibrosisSignaling pathwaysTRPV4Therapeutic target

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