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Systems genetic analysis of brown adipose tissue function.

Michal Pravenec1, Laura M Saba2, Václav Zídek1

  • 1Institute of Physiology of the Czech Academy of Sciences , Prague , Czech Republic.

Physiological Genomics
|November 12, 2017
PubMed
Summary

This study identifies novel genetic factors influencing brown adipose tissue (BAT) mass and function. These findings offer new insights into the genetic basis of metabolic syndrome traits.

Keywords:
brown adipose tissuecoexpression modulesquantitative trait locusrecombinant inbred strainsspontaneously hypertensive rat

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Area of Science:

  • Genetics
  • Metabolic Syndrome
  • Adipose Tissue Biology

Background:

  • Brown adipose tissue (BAT) plays a crucial role in regulating lipid and glucose metabolism.
  • Understanding the genetic underpinnings of BAT function is vital for metabolic health.

Purpose of the Study:

  • To identify genetic determinants of brown adipose tissue (BAT) mass and function using systems genetics approaches.
  • To uncover novel genes and pathways involved in BAT's role in metabolism.

Main Methods:

  • Utilized BXH/HXB recombinant inbred rat strains for genetic and correlation analyses.
  • Performed linkage analyses to identify quantitative trait loci (QTLs) for BAT mass and glucose metabolism.
  • Employed weighted gene coexpression network analysis (WGCNA) to identify gene modules associated with BAT traits.

Main Results:

  • Identified QTLs on chromosomes 4 and 2 associated with BAT mass, glucose oxidation, and lipid incorporation.
  • Discovered gene coexpression modules, Coral4.1 and Darkseagreen, linked to BAT relative mass and glucose metabolism, respectively.
  • Highlighted highly connected genes such as Cd36, Hiat1, Fmo5, and Sort1 within these modules.

Conclusions:

  • Systems genetic analysis confirmed known and revealed novel genetic factors influencing BAT function.
  • These genetic components are potentially involved in traits associated with the metabolic syndrome.