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Association between miR-146a rs2910164 polymorphism and specific cancer susceptibility: an updated meta-analysis

Xia Hao1, Lingzi Xia1, Ruoyi Qu1

  • 1China Medical University, Shenyang, China.

Familial Cancer
|November 12, 2017
PubMed

Insights

The miR-146a rs2910164 polymorphism is not linked to overall cancer risk. However, this genetic variation may increase susceptibility to lung cancer and nasopharyngeal carcinoma.

Area of Science:

  • Genetics and Oncology
  • Molecular Biology
  • Cancer Epidemiology

Background:

  • Cancer incidence is rising globally, impacting public health and mortality.
  • MicroRNAs (miRNAs) are increasingly recognized as potential biomarkers for cancer susceptibility.
  • The miR-146a rs2910164 polymorphism has been investigated for its role in various cancers.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between the miR-146a rs2910164 polymorphism and cancer susceptibility.
  • To explore potential links between this polymorphism and specific cancer types, ethnicities, and study designs.

Main Methods:

  • A meta-analysis was performed on 38 independent case-control studies, including 14,670 cancer cases and 20,235 controls.
  • Data were sourced from PubMed, and statistical analyses used odds ratios (ORs) and 95% confidence intervals (CIs).
  • Subgroup analyses were conducted based on cancer type, ethnicity, and study design using Stata 11.0 software.

Main Results:

  • The miR-146a rs2910164 polymorphism showed no significant association with overall cancer susceptibility across all genetic models.
  • Significant associations were observed between the polymorphism and increased susceptibility to lung cancer and nasopharyngeal carcinoma.
  • No significant associations were found for hepatocellular carcinoma or gastric cancer, nor in subgroup analyses by ethnicity or study design.

Conclusions:

  • The miR-146a rs2910164 polymorphism is not a general risk factor for all cancers.
  • This specific miRNA polymorphism may contribute to the susceptibility of developing lung cancer and nasopharyngeal carcinoma.
  • Further research is warranted to elucidate the precise mechanisms underlying these associations.
Keywords:
CancerMeta-analysisMiR-146aPolymorphismSusceptibility

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