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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
547
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
538
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

563
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Related Experiment Video

Updated: Feb 19, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Interventions for treating collagenous colitis.

Tahir S Kafil1, Tran M Nguyen, Petrease H Patton

  • 1Department of Medicine, University of Western Ontario, London, ON, Canada.

The Cochrane Database of Systematic Reviews
|November 12, 2017
PubMed
Summary
This summary is machine-generated.

This review found low-quality evidence that budesonide may effectively treat collagenous colitis, improving both clinical and histological responses. Evidence for other therapies like mesalamine and prednisolone remains uncertain, requiring further research.

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Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Pharmacology

Background:

  • Collagenous colitis is a condition characterized by chronic diarrhea.
  • This updated review focuses on therapies for collagenous colitis evaluated in randomized controlled trials (RCTs).

Purpose of the Study:

  • To assess the efficacy and safety of various treatments for collagenous colitis.
  • To identify therapies with robust evidence from randomized controlled trials.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) identified through comprehensive database searches (CENTRAL, Cochrane IBD Group Specialized Register, MEDLINE, EMBASE).
  • Included RCTs compared therapies against placebo or active comparators for active or quiescent collagenous colitis.
  • Data extraction and risk of bias assessment were performed independently by two authors, with GRADE criteria used for overall evidence quality.

Main Results:

  • Twelve RCTs involving 476 participants evaluated therapies including budesonide, mesalamine, bismuth subsalicylate, prednisolone, probiotics, and herbal extracts.
  • Budesonide demonstrated potential efficacy in inducing and maintaining clinical and histological response, with low-quality evidence.
  • Evidence for other agents like mesalamine, bismuth subsalicylate, and prednisolone was limited or uncertain, with some studies showing no significant benefit over placebo.

Conclusions:

  • Low-quality evidence suggests budesonide may be effective for collagenous colitis treatment.
  • The benefits and harms of bismuth subsalicylate, Boswellia serrata extract, mesalamine, prednisolone, and probiotics are uncertain.
  • Further high-quality research is needed to establish the efficacy and safety of these and other collagenous colitis therapies.