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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

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Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
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Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

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Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
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Psychological Responses to Stress01:20

Psychological Responses to Stress

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Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
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Traumatic Memory01:20

Traumatic Memory

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Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
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Related Experiment Video

Updated: Feb 19, 2026

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
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Transcriptome Alterations in Posttraumatic Stress Disorder.

Matthew J Girgenti1, Ronald S Duman1

  • 1Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

Biological Psychiatry
|November 13, 2017
PubMed
Summary
This summary is machine-generated.

Posttraumatic stress disorder (PTSD) gene expression is altered in the brain and blood. Next-generation sequencing technologies like RNA sequencing help identify these molecular changes in PTSD patients.

Keywords:
GenomicsPTSDPrefrontal cortexRNA sequencingStressTranscriptomics

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Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Posttraumatic stress disorder (PTSD) affects nearly 8% of the population.
  • The molecular mechanisms underlying PTSD are not fully understood.
  • Aberrant gene expression in brain and blood cells is linked to PTSD.

Purpose of the Study:

  • To review transcriptomic technologies for PTSD research.
  • To summarize gene expression studies in human blood and animal models of PTSD.
  • To analyze human PTSD postmortem brain gene profiling studies.

Main Methods:

  • Overview of next-generation sequencing (NGS) technologies.
  • RNA sequencing for transcriptomic analysis (gene expression, splicing, novel transcripts, noncoding RNAs).
  • Review of existing human and animal PTSD gene expression studies.

Main Results:

  • NGS technologies, particularly RNA sequencing, enable detailed analysis of gene expression.
  • Studies show altered gene expression patterns in peripheral blood and brain tissue in PTSD.
  • Data from human and animal models provide insights into PTSD molecular pathology.

Conclusions:

  • Transcriptomic technologies are crucial for understanding PTSD molecular mechanisms.
  • Gene expression profiling in blood and brain offers potential biomarkers and therapeutic targets for PTSD.
  • Further research using these technologies can elucidate PTSD pathogenesis.