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Post-Orgasmic Illness Syndrome: A Review.

Hoang Minh Tue Nguyen1, Areeg Bala1, Andrew T Gabrielson1

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|November 13, 2017
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Summary
This summary is machine-generated.

Post-orgasmic illness syndrome (POIS) is a rare, debilitating condition causing flu-like symptoms after ejaculation. Current research reviews POIS pathophysiology and management, highlighting the need for further investigation into this underdiagnosed disorder.

Keywords:
Ejaculation DisorderPost-Orgasmic Illness Syndrome

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Area of Science:

  • Reproductive Medicine
  • Urology
  • Immunology

Background:

  • Post-orgasmic illness syndrome (POIS) is a rare, chronic condition characterized by debilitating post-ejaculatory symptoms.
  • Symptoms include flu-like and allergic manifestations, alongside mental sequelae like irritability and diminished concentration.
  • The condition significantly impacts patients' quality of life, limiting sexual activity and social interactions.

Purpose of the Study:

  • To provide an updated review of the current literature on Post-orgasmic illness syndrome (POIS).
  • To elucidate the pathophysiology of POIS.
  • To discuss potential management strategies for POIS.

Main Methods:

  • A comprehensive review of existing literature on Post-orgasmic illness syndrome (POIS) was conducted.

Main Results:

  • POIS presents with 5 preliminary diagnostic criteria and is classified as primary or secondary.
  • The autoimmune-allergy hypothesis is the leading theory for POIS pathogenesis, with alternative hypotheses involving μ-opioid receptors or cytokine/neuroendocrine responses.
  • While no definitive treatments exist, symptomatic management includes antihistamines, SSRIs, and benzodiazepines; one case reported success with hyposensitization therapy using autologous semen.

Conclusions:

  • Post-orgasmic illness syndrome (POIS) is underdiagnosed and under-reported, necessitating further research.
  • Additional studies are crucial to understand the prevalence, underlying pathophysiology, and effective treatments for POIS.
  • The review underscores the need for increased awareness and investigation into this debilitating condition.