Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lymphocytic ("microscopic") colitis: a comparative histopathologic study with particular reference to collagenous

A J Lazenby1, J H Yardley, F M Giardiello

  • 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Human Pathology
|January 1, 1989
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Syphilitic gumma presenting as squamous cell carcinoma of Vulva: A case report.

Gynecologic oncology reports·2024
Same author

Retinoic acid receptor β2 agonists restore glycaemic control in diabetes and reduce steatosis.

Diabetes, obesity & metabolism·2015
Same author

[Risk factors for inactivity in patients in long-term care with severe mental illness].

Tijdschrift voor psychiatrie·2013
Same author

Colorectal cancer in ulcerative colitis: survival in patients with and without colorectal cancer symptoms.

Inflammatory bowel diseases·2013
Same author

Mucosal prolapse syndrome presenting as rectal polyposis.

Journal of clinical pathology·2009
Same author

[Cholesterol gallstone pathogenesis].

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion·2009

Lymphocytic colitis, previously microscopic colitis, is characterized by increased intraepithelial lymphocytes and epithelial damage. This study distinguishes it from collagenous colitis and other forms of colitis.

Area of Science:

  • Gastroenterology
  • Histopathology
  • Colorectal Diseases

Background:

  • Lymphocytic colitis, formerly microscopic colitis, presents with watery diarrhea and normal colonoscopy.
  • Its distinct histopathologic features require detailed characterization.

Purpose of the Study:

  • To compare the histopathology of lymphocytic colitis with collagenous colitis, idiopathic inflammatory bowel disease, acute colitis, and normal colonic tissue.
  • To establish diagnostic criteria for lymphocytic colitis.

Main Methods:

  • A blinded, semiquantitative analysis of histologic features was performed on biopsy samples.
  • Key features examined included intraepithelial lymphocytes, surface epithelial damage, lamina propria inflammation, and crypt changes.

Main Results:

Related Experiment Videos

  • Lymphocytic colitis showed significantly increased intraepithelial lymphocytes (P = .0001) and surface epithelial damage (P < .005).
  • Distinctive features included minimal crypt distortion and active cryptitis.
  • Similarities with collagenous colitis were noted, but subepithelial collagen thickening was absent.

Conclusions:

  • Lymphocytic colitis is a distinct entity characterized by prominent lymphocytic infiltration of the epithelium.
  • It can be differentiated from collagenous colitis, idiopathic inflammatory bowel disease, and acute colitis on biopsy.
  • The term lymphocytic colitis is a more accurate designation than microscopic colitis.