Related Experiment Video

Updated: Feb 19, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

2.7K

The initial prophylactic antibiotic usage and subsequent necrotizing enterocolitis in high-risk premature infants: a

Xue Fan1,2, Li Zhang1,2, Jun Tang3,4

  • 1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Pediatric Surgery International
|November 13, 2017
PubMed

Insights

Prophylactic antibiotic use in premature infants did not reduce the incidence of necrotizing enterocolitis (NEC). Prolonged antibiotic exposure showed a trend toward increased NEC risk, suggesting current practices should be re-evaluated.

Area of Science:

  • Neonatalogy
  • Pediatric Infectious Diseases
  • Clinical Pharmacy

Background:

  • Necrotizing enterocolitis (NEC) is a serious gastrointestinal condition affecting premature infants.
  • Prophylactic antibiotic use is sometimes employed in high-risk neonates, but its efficacy in preventing NEC is debated.

Purpose of the Study:

  • To evaluate the association between prophylactic antibiotic administration and the subsequent development of NEC in high-risk premature infants.

Main Methods:

  • A comprehensive literature search was conducted across major databases (PubMed, EMBASE, CENTRAL, Web of Science).
  • Nine studies involving 5207 infants were included in this meta-analysis.

Main Results:

  • Overall prophylactic antibiotic use showed a non-significant trend towards increased NEC incidence (OR 0.75; 95% CI 0.26-2.17).
  • Prolonged exposure to prophylactic antibiotics was significantly associated with an increased risk of NEC (OR 1.31; 95% CI 1.08-1.59) compared to limited use.

Conclusions:

  • Existing evidence does not support the routine use of prophylactic antibiotics to prevent NEC in high-risk premature infants.
  • The findings suggest that prolonged antibiotic exposure may even increase NEC risk.
Abstract

Keywords:
AntibioticMeta-analysisNECPremature infantsProphylactic

More Related Videos

Probiotic Studies in Neonatal Mice Using Gavage10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

20.9K
Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation09:02

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

20.0K

Related Concept Videos

Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.4K
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
477
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
289
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
344