Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
General Case of Eccentric Axial Loading01:12

General Case of Eccentric Axial Loading

Unsymmetrical bending occurs when the bending moment applied to a structural member does not align with its principal axis. This misalignment leads to complex stress distributions and deflection patterns that differ from symmetrical bending, which are essential for designing structures to withstand different loading conditions.
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical bending,...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Caloric restriction attenuates age-related liver and kidney alterations in mice: Histological evidence.

Histology and histopathology·2026
Same author

[Lower gastrointestinal bleeding secondary to Chronic Nonspecific Ulcerative Colitis: A clinical case].

Revista medica del Instituto Mexicano del Seguro Social·2026
Same author

[Brown tumor due to hyperparathyroidism secondary to chronic kidney disease: A clinical case].

Revista medica del Instituto Mexicano del Seguro Social·2025
Same author

Association Between Telomere Shortening and Erythropoietin Resistance in Patients with Chronic Kidney Disease Undergoing Hemodialysis.

International journal of molecular sciences·2025
Same author

The Role of Adenosine in Overcoming Resistance in Sarcomas.

International journal of molecular sciences·2024
Same author

Association of hTERT expression, Her2Neu, estrogen receptors, progesterone receptors, with telomere length before and at the end of treatment in breast cancer patients.

Frontiers in medicine·2024

Related Experiment Video

Updated: Jul 13, 2026

Calibrated Forceps Model of Spinal Cord Compression Injury
09:41

Calibrated Forceps Model of Spinal Cord Compression Injury

Published on: April 24, 2015

19.4K

Multiple hereditary osteochondromatosis with spinal cord compression: case report.

Oscar García-González1,2, J Nicolás Mireles-Cano3, Natalia Sánchez-Zavala4

  • 1Hospital Regional de Alta especialidad del Bajío, León, Guanajuato, Mexico. oggarciagonzalez@gmail.com.

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|November 13, 2017
PubMed
Summary

Hereditary osteochondromatosis can cause spinal cord compression. Surgical removal of a thoracic bony tumor relieved paralysis in an 8-year-old patient with this condition.

Keywords:
Multiple hereditary exostosisSpinal cord compressionTranssternal approach

More Related Videos

A Neonatal Mouse Spinal Cord Compression Injury Model
13:31

A Neonatal Mouse Spinal Cord Compression Injury Model

Published on: March 27, 2016

13.3K
Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
07:00

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Published on: May 7, 2019

9.4K

Related Experiment Videos

Last Updated: Jul 13, 2026

Calibrated Forceps Model of Spinal Cord Compression Injury
09:41

Calibrated Forceps Model of Spinal Cord Compression Injury

Published on: April 24, 2015

19.4K
A Neonatal Mouse Spinal Cord Compression Injury Model
13:31

A Neonatal Mouse Spinal Cord Compression Injury Model

Published on: March 27, 2016

13.3K
Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
07:00

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Published on: May 7, 2019

9.4K

Area of Science:

  • Neurosurgery
  • Orthopedic Surgery
  • Genetics

Background:

  • Hereditary osteochondromatosis (multiple hereditary exostosis) is a genetic disorder characterized by the development of multiple benign bone tumors.
  • Spinal involvement can lead to serious neurological complications, including spinal cord compression.

Observation:

  • An 8-year-old male with a family history of hereditary osteochondromatosis presented with progressive paraparesis.
  • Neurological examination revealed complete paralysis in both lower extremities.

Findings:

  • Imaging revealed a bony tumor at the T3 level compressing the spinal cord, with associated hydrosyringomyelia extending to the conus medullaris.
  • Surgical resection of the tumor via an anterior thoracic approach (T2-T4) and subsequent stabilization with a bone graft and plate.
  • Post-operative recovery showed significant improvement in motor function within two months.

Implications:

  • Early diagnosis and surgical intervention are crucial for managing spinal cord compression in hereditary osteochondromatosis.
  • Advanced imaging and family history are vital for comprehensive patient management.
  • Successful surgical decompression and stabilization can lead to substantial neurological recovery.