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Related Concept Videos

Vaccinations01:51

Vaccinations

52.0K
Overview
52.0K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

244
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
244
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

289
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
289
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

272
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
272
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

730
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
730
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

235
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
235

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Related Experiment Video

Updated: Feb 19, 2026

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
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Vaccinations in Older Adults.

Megan Burke1, Theresa Rowe2

  • 1Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, 5200 Eastern Avenue, MFL Center Tower, Suite 2200, Baltimore, MD 21224, USA.

Clinics in Geriatric Medicine
|November 14, 2017
PubMed
Summary

Vaccines are crucial for older adults to prevent serious infections. Low vaccination rates in adults aged 65 and over are linked to cost and other factors, despite recommended immunizations.

Keywords:
Herpes zosterImmune senescenceImmunizationsInfluenzaOlder adultsPneumococcalVaccinations

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Area of Science:

  • Gerontology
  • Immunology
  • Public Health

Background:

  • Older adults (≥65 years) face higher risks of severe illness from vaccine-preventable diseases.
  • Age-related immune decline and chronic conditions exacerbate these risks.
  • Current vaccination rates among seniors are suboptimal despite established guidelines.

Purpose of the Study:

  • To highlight the importance of key vaccinations for adults aged 65 and older.
  • To identify factors contributing to low vaccination uptake in this demographic.

Main Methods:

  • Review of current vaccination guidelines for older adults.
  • Analysis of factors influencing vaccine acceptance and uptake in the elderly population.

Main Results:

  • Key recommended vaccines include influenza, pneumococcal, herpes zoster, tetanus, diphtheria, and pertussis (Tdap), and hepatitis B.
  • Financial cost is a significant barrier to vaccination for many older adults.
  • Despite recommendations, vaccination coverage remains low.

Conclusions:

  • Vaccinations are essential for protecting older adults from preventable infectious diseases.
  • Addressing cost barriers and improving access are critical to increasing vaccination rates.
  • Enhanced public health strategies are needed to promote timely immunizations in seniors.