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Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
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Esophageal Strictures-I: Introduction01:30

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Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
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Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
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Esophageal Strictures-II: Clinical Features and Management01:26

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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
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Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
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Future Directions in Eosinophilic Esophagitis.

Ikuo Hirano1

  • 1Division of Gastroenterology, Northwestern University Feinberg School of Medicine, 676 North Saint Clair, Suite 1400, Chicago, IL 60611, USA.

Gastrointestinal Endoscopy Clinics of North America
|November 14, 2017
PubMed
Summary
This summary is machine-generated.

Eosinophilic esophagitis (EoE) is increasing, prompting advances in diagnosis and treatment. New methods are being developed to assess disease activity, potentially reducing the need for invasive procedures.

Keywords:
DysphagiaEosinophilic esophagitisEsophageal strictureEsophagitisFood allergyGastroesophageal reflux disease

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Area of Science:

  • Gastroenterology and Immunology
  • Esophageal Diseases
  • Inflammatory Pathways

Background:

  • Rising prevalence of eosinophilic esophagitis (EoE).
  • Need for refined diagnostic criteria and risk factor identification.
  • Growing understanding of EoE's inflammatory and remodeling components.

Purpose of the Study:

  • To review recent developments in understanding and managing eosinophilic esophagitis.
  • To highlight advancements in diagnostic criteria, therapeutic strategies, and outcome measures.
  • To explore less-invasive methods for assessing disease activity.

Main Methods:

  • Review of current literature and clinical trial data.
  • Analysis of emerging diagnostic and therapeutic modalities.
  • Evaluation of novel endpoints, including endoscopic and non-invasive assessments.

Main Results:

  • Diagnostic criteria for EoE have been refined.
  • Endoscopic outcomes are key endpoints in novel therapeutic trials.
  • The functional lumen imaging probe shows potential as a non-invasive endpoint.

Conclusions:

  • Significant progress has been made in EoE research and clinical practice.
  • Optimizing dietary therapy and biological agents are key treatment strategies.
  • Development of less-invasive assessment tools is crucial for patient management.