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In situ neoplasia in lymph node pathology.

Naoki Oishi¹, Santiago Montes-Moreno², Andrew L Feldman³

¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA; Department of Pathology, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.

Seminars in Diagnostic Pathology

|November 14, 2017

Summary

This review covers early-stage lymphoid cancers, specifically in situ follicular neoplasia (ISFN) and in situ mantle cell neoplasia (ISMCN). It details their characteristics, diagnosis, and differentiation from related conditions.

Keywords:

14)18)Follicular lymphoma In situ follicular neoplasia In situ mantle cell neoplasia Lymphomagenesis Mantle cell lymphoma t(11 t(14

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Area of Science:

Hematology
Oncology
Pathology

Background:

In situ neoplasia signifies the initial stage of malignant progression, confined to the cell's origin compartment.
Lymphoid neoplasms, like other cancers, arise through multistep pathogenetic processes.
Identifying in situ lymphoid neoplasia histopathologically is challenging due to lymphocyte circulation and physiological compartment restriction.

Purpose of the Study:

To review the clinical features, histopathology, and genetics of in situ follicular neoplasia (ISFN) and in situ mantle cell neoplasia (ISMCN).
To outline the differential diagnoses for these entities.
To distinguish ISFN and ISMCN from their malignant counterparts and reactive processes.

Main Methods:

Literature review of the 2016 WHO classification of lymphoid neoplasms.
Synthesis of clinical, histopathological, and genetic data for ISFN and ISMCN.
Comparative analysis with malignant lymphoid neoplasms and reactive conditions.

Main Results:

The 2016 WHO classification identifies ISFN and ISMCN as distinct in situ lymphoid entities.
These entities present unique clinical, histopathological, and genetic profiles.
Accurate differentiation from malignant and reactive mimics is crucial for diagnosis.

Conclusions:

In situ lymphoid neoplasia requires careful histopathological evaluation due to its unique characteristics.
Understanding ISFN and ISMCN is essential for accurate diagnosis and patient management.
Further research may refine diagnostic criteria and therapeutic strategies for early-stage lymphoid malignancies.