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Related Experiment Videos

Auger electron contribution to bromodeoxyuridine cellular radiosensitization.

D Larson1, W J Bodell, C Ling

  • 1Department of Radiation Oncology, University of California, San Francisco 94143.

International Journal of Radiation Oncology, Biology, Physics
|January 1, 1989
PubMed
Summary

Bromodeoxyuridine (BUdR) enhances tumor radiosensitization, but its mechanism is unclear. This study found that Auger electrons from BUdR contribute minimally to radiosensitization, suggesting other mechanisms are more significant.

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Area of Science:

  • Radiotherapy
  • Radiation Biology
  • Medical Physics

Background:

  • Halogenated thymidine analogs like bromodeoxyuridine (BUdR) incorporate into DNA during S-phase.
  • BUdR can radiosensitize tumors, improving radiation therapy effectiveness.
  • The precise mechanisms of BUdR-induced radiosensitization remain poorly understood.

Purpose of the Study:

  • To investigate the role of Auger electrons in BUdR-mediated radiosensitization.
  • To determine if photoelectric absorption of X-rays by bromine's K-shell in BUdR contributes to radiosensitization.

Main Methods:

  • Cultured Chinese hamster V79 cells with 32% thymidine replacement by BUdR were used.
  • Cells were exposed to monoenergetic X-rays precisely below (13.450 KeV) and above (13.490 KeV) the bromine K-edge (13.475 KeV).

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  • Enhancement ratios were calculated using various methods, including linear-quadratic fitting.

    • Main Results:

    • A slight increase (3-12%) in enhancement ratios was observed above the bromine K-edge compared to below.
    • Only a linear-quadratic fit analysis with a surviving fraction of 0.01 showed a statistically significant (12%) increase in enhancement ratio above the K-edge.
    • These findings indicate a minimal contribution of Auger electrons to BUdR radiosensitization.

    Conclusions:

    • Auger electrons generated by X-ray photoelectric absorption on the bromine K-shell in BUdR contribute minimally to observed cellular radiosensitization.
    • The primary mechanisms of BUdR-mediated radiosensitization likely involve factors other than Auger electron release.