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Hyperthermic "dose" dependent changes in intralesional pH.

F W Hetzel1, K Avery, M Chopp

  • 1Department of Neurology, Henry Ford Hospital, Detroit, MI.

International Journal of Radiation Oncology, Biology, Physics
|January 1, 1989
PubMed
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Hyperthermia treatment causes a significant drop in tumor pH. Tumor pH recovers over approximately 3 days, with higher doses resulting in lower recovery levels.

Area of Science:

  • Oncology
  • Biophysics
  • Cancer Research

Background:

  • Hyperthermia is a cancer treatment modality.
  • Intra-lesional pH drops have been observed following hyperthermia in experimental tumors.
  • The time course and recovery of these pH changes are not well-documented.

Purpose of the Study:

  • To measure the time course of intra-lesional pH changes following hyperthermia.
  • To investigate the recovery of intra-lesional pH over prolonged periods.
  • To correlate pH changes with specific hyperthermia doses related to biological endpoints.

Main Methods:

  • Experiments were conducted using the C3H-mammary carcinoma tumor model.
  • Intra-lesional temperature was continuously monitored during hyperthermia treatment.

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  • Post-treatment intra-lesional pH was measured using microelectrodes at various time points (4 hours to 7 days).

    • Main Results:

    • Pretreatment mean pH was 6.73.
    • At the TCD90 (tumor-clearing dose) level, mean pH dropped to 6.22 +/- 0.095.
    • At the TCD10 level, mean pH was 6.55 +/- 0.148.
    • pH recovery occurred over approximately 3 days post-treatment.
    • Higher hyperthermia doses resulted in lower pH recovery levels.

    Conclusions:

    • Hyperthermia induces a significant and dose-dependent drop in intra-lesional pH.
    • Tumor pH demonstrates a recovery pattern over several days post-treatment.
    • The extent of pH recovery is influenced by the hyperthermia dose, with higher doses leading to sustained lower pH levels.