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Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
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APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription

Yanmeng Chen1, Jie Hu1, Xuefei Cai1

  • 1Key Laboratory of Molecular Biology on Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, 1 Yi Xue Yuan Road, Yuzhong District, Chongqing 400016, People's Republic of China.

Antiviral Research
|November 14, 2017
PubMed
Summary

The cellular protein APOBEC3B restricts Hepatitis B virus (HBV) replication by editing viral DNA during reverse transcription. This protein interacts with HBV core protein, offering multifaceted antiviral defense against HBV.

Keywords:
APOBEC3BDeaminaseHepatitis B virusInhibition

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