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Updated: Feb 19, 2026
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Fluorescence and Bioluminescence Imaging of Subcellular Ca2+ in Aged Hippocampal Neurons
Published on: December 1, 2015
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Cellular calcium signaling in the aging brain
Remya Chandran1, Mantosh Kumar2, Lakshmi Kesavan2
1Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Palayad, Kannur, Kerala, 670 661, India.
Journal of Chemical Neuroanatomy
|November 14, 2017
Summary
Biological aging is irreversible, impacting survival. This review summarizes age-related changes in brain calcium signaling, a key process implicated in neuronal function and aging diseases.
Area of Science:
- Neuroscience
- Gerontology
- Molecular Biology
Background:
- Biological aging is an irreversible process affecting organismal survival and function.
- Aging is linked to cellular and molecular alterations, notably in calcium signaling pathways.
- Calcium signaling is crucial for brain function, with impairments potentially leading to neuronal death.
Purpose of the Study:
- To review the age-associated alterations in calcium signaling within the brain.
- To highlight the significance of calcium signaling proteins as therapeutic targets for aging-related neurological disorders.
Main Methods:
- Literature review of studies investigating calcium signaling and aging in the brain.
- Analysis of molecular and cellular changes in calcium homeostasis during the aging process.
Main Results:
- Aging significantly alters calcium signaling dynamics in various brain regions.
- Impaired calcium regulation contributes to age-related cognitive decline and neurodegeneration.
- Calcium signaling proteins represent viable targets for interventions against brain aging.
Conclusions:
- Age-related changes in brain calcium signaling are a critical factor in functional decline.
- Understanding these alterations is essential for developing strategies to mitigate aging effects on the brain.
- Targeting calcium signaling pathways offers potential therapeutic avenues for age-related neurological conditions.
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