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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Calmodulin-dependent Signaling01:16

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Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Feedback Regulation of Calcium Concentration01:27

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Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Updated: Feb 19, 2026

Fluorescence and Bioluminescence Imaging of Subcellular Ca2+ in Aged Hippocampal Neurons
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Cellular calcium signaling in the aging brain.

Remya Chandran1, Mantosh Kumar2, Lakshmi Kesavan2

  • 1Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Palayad, Kannur, Kerala, 670 661, India.

Journal of Chemical Neuroanatomy
|November 14, 2017
PubMed
Summary

Biological aging is irreversible, impacting survival. This review summarizes age-related changes in brain calcium signaling, a key process implicated in neuronal function and aging diseases.

Keywords:
AgingAging associated neurodegenerative diseaseCalcium channelsCalcium signalingExcitotoxicityNeuronal calcium homeostasisOxidative stress

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Area of Science:

  • Neuroscience
  • Gerontology
  • Molecular Biology

Background:

  • Biological aging is an irreversible process affecting organismal survival and function.
  • Aging is linked to cellular and molecular alterations, notably in calcium signaling pathways.
  • Calcium signaling is crucial for brain function, with impairments potentially leading to neuronal death.

Purpose of the Study:

  • To review the age-associated alterations in calcium signaling within the brain.
  • To highlight the significance of calcium signaling proteins as therapeutic targets for aging-related neurological disorders.

Main Methods:

  • Literature review of studies investigating calcium signaling and aging in the brain.
  • Analysis of molecular and cellular changes in calcium homeostasis during the aging process.

Main Results:

  • Aging significantly alters calcium signaling dynamics in various brain regions.
  • Impaired calcium regulation contributes to age-related cognitive decline and neurodegeneration.
  • Calcium signaling proteins represent viable targets for interventions against brain aging.

Conclusions:

  • Age-related changes in brain calcium signaling are a critical factor in functional decline.
  • Understanding these alterations is essential for developing strategies to mitigate aging effects on the brain.
  • Targeting calcium signaling pathways offers potential therapeutic avenues for age-related neurological conditions.