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A Case of Probable Amisulpride Induced Mania after Eight Months of Therapy

Prakash Thapa1, Rajasee Sharma2

  • 1Department of Psychiatry, Manipal Teaching Hospital, Fulbari 11, Pokhara, Nepal.

Case Reports in Psychiatry
|November 14, 2017
PubMed

Insights

Manic symptoms are a rare side effect of amisulpride, an atypical antipsychotic. This case study details a patient who developed mania after eight months of amisulpride treatment for schizophrenia.

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Atypical antipsychotics are commonly used for schizophrenia treatment.
  • Manic symptoms are a known, albeit rare, side effect of atypical antipsychotics.
  • Reports of amisulpride-induced mania are infrequent in existing literature.

Observation:

  • An 18-year-old male diagnosed with schizophrenia was treated with amisulpride.
  • The patient developed manic symptoms after approximately eight months of continuous amisulpride therapy.
  • This onset is notably longer than previously reported cases.

Findings:

  • This case highlights a delayed onset of amisulpride-induced mania.
  • The study explores potential risk factors contributing to this delayed reaction.
  • Amisulpride may induce mania even after prolonged treatment periods.

Implications:

  • Clinicians should remain vigilant for manic symptoms in patients on long-term amisulpride treatment.
  • Further research is needed to understand the mechanisms and risk factors for delayed amisulpride-induced mania.
  • This finding may inform treatment guidelines and patient monitoring protocols for schizophrenia.

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