Related Experiment Video

Updated: Feb 18, 2026

Histological Quantification of Chronic Myocardial Infarct in Rats
09:45

Histological Quantification of Chronic Myocardial Infarct in Rats

Published on: December 11, 2016

15.5K

Correlation of Leukocyte and Coronary Lesion Severity of Acute Myocardial Infarction

Yunting Liang1,2, Hui Chen3,2, Ping Wang3

  • 11 Department of Pediatric Cardiovascular Center, Anzhen Hospital, Beijing, China.

Angiology
|November 14, 2017
PubMed

Insights

Higher leukocyte and neutrophil counts, along with the neutrophil-lymphocyte ratio (NLR), are linked to severe coronary lesions in acute myocardial infarction (AMI) patients. Neutrophil count may predict high thrombus burden and total coronary occlusion.

Area of Science:

  • Cardiology
  • Hematology
  • Biomedical Science

Background:

  • Leukocytes are crucial in acute myocardial infarction (AMI) development and progression.
  • Understanding the link between leukocyte counts and coronary lesion severity is vital for patient management.

Purpose of the Study:

  • To investigate the association between leukocyte count and coronary lesion severity in patients with AMI.
  • To determine if leukocyte count, neutrophil count, or neutrophil-lymphocyte ratio (NLR) predict adverse cardiovascular events during hospitalization.

Main Methods:

  • A retrospective study of 815 AMI patients undergoing primary percutaneous coronary intervention (2005-2014).
  • Analysis of risk factors, routine blood parameters, and in-hospital cardiovascular events.
  • Comparison of leukocyte counts, neutrophil counts, and NLR between thrombus burden and total occlusion groups.

Main Results:

  • Leukocyte count, neutrophil count, and NLR were significantly higher in patients with high thrombus burden and total coronary occlusion.
  • A neutrophil count ≥8.355 × 10^9/L was independently associated with high thrombus burden and total coronary occlusion.
  • No significant relationship was found between leukocyte count, neutrophil count, NLR, and in-hospital cardiovascular events.

Conclusions:

  • Neutrophil count may serve as an independent predictor of high thrombus burden and total coronary occlusion in AMI patients.
  • Leukocyte parameters are associated with coronary lesion severity but not necessarily with in-hospital cardiovascular events.

Keywords:
acute myocardial infarctionleukocyte countneutrophil countneutrophil–lymphocyte ratio

More Related Videos

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia12:42

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia

Published on: December 28, 2014

16.2K
Simultaneous 3D Analysis of Cardiac Damage and Immune Response in Reperfused Acute Myocardial Infarction Using Light Sheet Fluorescence Microscopy06:38

Simultaneous 3D Analysis of Cardiac Damage and Immune Response in Reperfused Acute Myocardial Infarction Using Light Sheet Fluorescence Microscopy

Published on: September 26, 2025

1.2K

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
309
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
477
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.1K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
460
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
585
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
437