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Cisplatin-conjugated gold nanoparticles as a theranostic agent for head and neck cancer
Erez Shmuel Davidi1, Tamar Dreifuss2, Menachem Motiei2
1Department of Otolaryngology Head and Neck Surgery, Kaplan Medical Center, Rehovot, Israel.
Background:
The purpose of this study was to develop a nanoplatform, which simultaneously acts as radiosensitizer, drug carrier, and tumor imaging agent for head and neck cancer.
Methods:
We synthesized 20 nm gold nanoparticles, coated with glucose and cisplatin (CG-GNPs). Their penetration into tumor cells and their cellular toxicity were evaluated in vitro. In vivo experiments were conducted to evaluate their impact on tumor growth and their imaging capabilities.
Results:
The CG-GNPs showed efficient penetration into tumor cells and similar cellular toxicity as cisplatin alone. Combined with radiation, CG-GNPs led to greater tumor reduction than that of radiation alone and radiation with free cisplatin. The CG-GNPs also demonstrated efficient tumor imaging capabilities.
Conclusion:
Our CG-GNPs have a great potential to increase antitumor effect, overcome resistance to chemotherapeutics and radiation, and allow imaging-guided therapy.
