Related Experiment Video
Updated: Feb 18, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
Nutritional practices in very low birth weight infants: a national survey
Miguel Sáenz de Pipaón, Ricardo Closa, María Gormaz
1Paediatrics Service. University Rovira i Virgili, Reus. gerard@unizar.es.
Insights
Most neonatal units provide early amino-acid and fish oil-based lipid emulsions for very low birth weight (VLBW) infants. However, vitamin D and post-discharge nutrition practices show significant variation among centers.
Area of Science:
- Neonatal Nutrition
- Pediatric Gastroenterology
- Clinical Practice Surveys
Background:
- Improving nutritional support for very preterm infants is a key focus in neonatal care.
- Large-scale surveys are crucial for understanding current nutritional practices in neonatal units.
- Assessing adherence to established guidelines for preterm infant nutrition is essential.
Purpose of the Study:
- To investigate the current clinical feeding practices for very low birth weight (VLBW) infants in tertiary neonatal hospitals.
- To evaluate the alignment of these practices with existing nutritional guidelines.
- To identify variations in nutritional support strategies across different neonatal units.
Main Methods:
- A multicentre, nationwide, web-based survey was conducted.
- The survey targeted tertiary neonatal hospitals admitting infants with birth weight < 1,500 g or gestational age < 32 weeks.
- Data were collected from 53 units, achieving a 59% response rate.
Main Results:
- Over 90% of units initiate amino-acid administration immediately after birth; more than half utilize fish oil-based lipid emulsions.
- Enteral nutrition begins within 24 hours in 65% of units, with feeding volumes increased by 10-30 ml/kg/day in over 90%.
- Human milk fortification and iron supplementation are nearly universal, but vitamin D administration (800 IU/day) is low (30%), and 50% of units use preterm formula at discharge.
Conclusions:
- Spanish neonatology units commonly employ early amino-acid and novel fish oil-based lipid emulsions for VLBW infants.
- Significant variability exists in post-discharge nutrition strategies and vitamin D supplementation.
- Further standardization of nutritional protocols, particularly for vitamin D and discharge feeding, is warranted.
Background:
Significant efforts have been made to improve the nutritional support of very preterm infants. Large surveys may help to know the nutritional practices for preterm infants in neonatal units and identify if they are in line with the current guidelines.
Methods:
A multicentre nationwide web-based survey on clinical feeding practices in very low birth weight (VLBW) infants was conducted in tertiary neonatal hospitals that admit infants with a birth weight < 1,500 g and/or a gestational age of < 32 weeks.
Results:
The questionnaire was completed by 53 units (response rate, 59%). Over 90% of the units surveyed start amino-acid administration immediately after birth and more than half use novel intravenous fish oil-based lipid emulsions. Enteral nutrition is started within 24 hours of birth in 65% of units and 86% of these are medium-sized or large. Feeding volumes are increased at a rate of 10-30 ml/kg/day in > 90% of units. Monitoring of serum phosphorus was measured more frequently than albumin (p = 0.009) or triglycerides (p = 0.037), but only 28% of centres regularly measure pre-albumin as a nutritional biomarker. Human milk fortification and iron supplementation, starting at four weeks of age, are almost universal. However, only 30% of units administer 800 IU/day of vitamin D. Nearly 50% of the units discharge infants on preterm formula.
Conclusion:
Most Spanish neonatology units use early amino-acid supplementation and over half use novel fish oil-based lipid emulsions. Post-discharge nutrition practices and vitamin administration vary greatly.
More Related Videos
05:04A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect
Published on: September 22, 2023
19:15Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Related Concept Videos
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
Enteral Nutrition I: Orogastric and Nasogastric Feeding
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...