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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.6K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

84.5K
Overview
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Feb 18, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

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Immunosuppression/Infections across Indications.

Ayida Al-Khalili, Jan P Dutz

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    This summary is machine-generated.

    Cytokine inhibitors, including biologics, effectively treat psoriasis with a low infection risk. Special care is needed for patients with certain infections or before surgery.

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    In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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    Area of Science:

    • Immunodermatology
    • Pharmacology
    • Infectious Diseases

    Background:

    • Psoriasis treatment increasingly utilizes cytokine inhibitors, such as biologics, due to proven efficacy and safety.
    • Cytokines are crucial signaling molecules involved in coordinating immune responses, particularly against infectious threats.

    Purpose of the Study:

    • To review existing data on the immunosuppressive effects of cytokine inhibitors used for psoriasis.
    • To assess the infection risk associated with these psoriasis treatments.

    Main Methods:

    • Comprehensive review of data from clinical trials, patient registries, and cohort studies.
    • Analysis focused on immunosuppressive effects and infection risks of cytokine inhibitors in psoriasis patients.

    Main Results:

    • Cytokine inhibitors demonstrate efficacy and safety in treating psoriasis.
    • The overall risk of infection associated with these medications is minimal.

    Conclusions:

    • Cytokine inhibitors are valuable therapeutic options for psoriasis.
    • Careful consideration is required for patients with specific infections (granulomatous, viral hepatitis, HIV, fungal) and in the perioperative period.