Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Versatile SI-ATRP Growth of Methacrylate Brushes on Superparamagnetic Iron Oxide Nanoparticles Enables Methotrexate-Mediated Antineoplastic Activity in MCF-7 Cells.

Pharmaceutics·2026
Same author

Deciphering unusually large modulations in two related organic hydroxy channel structures.

Acta crystallographica Section B, Structural science, crystal engineering and materials·2026
Same author

Steric Control of Cooperative Anion Transport Mediated by β- and δ‑Hexachlorocyclohexane Multivalent Carriers.

JACS Au·2026
Same author

Selective Nitrate Transmembrane Transport Through Adaptive Weak C─H Bonding Cyanostilbene Water Channels.

Angewandte Chemie (International ed. in English)·2026
Same author

Dextran-driven hyperbranched black gold nanoparticles templated by guanosine quartets as broadband absorbers for photothermal therapy.

International journal of biological macromolecules·2026
Same author

Photo-modulation of proton/water transmembrane transport through bis(imidazole-amide)-tetrafluoro-azobenzene switch.

Faraday discussions·2026

Related Experiment Video

Updated: Feb 18, 2026

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models
10:49

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Published on: June 16, 2022

3.1K

G-Quartet hydrogels for effective cell growth applications.

Alexandru Rotaru1, Gabriela Pricope, Taylor N Plank

  • 1"Petru Poni" Institute of Macromolecular Chemistry, Centre Advanced Research in Bionanoconjugates and Biopolymers, 41A, Gr. Ghica Voda, 700487 Iasi, Romania.

Chemical Communications (Cambridge, England)
|November 14, 2017
PubMed
Summary
This summary is machine-generated.

Natural guanosine hydrogels cross-linked with benzene-1,4-diboronic acid and magnesium ions effectively support cell growth. These functional G-quartet hydrogels show no signs of degradation, indicating promising biomaterial applications.

More Related Videos

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

12.0K
Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications
08:50

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

7.3K

Related Experiment Videos

Last Updated: Feb 18, 2026

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models
10:49

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Published on: June 16, 2022

3.1K
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

12.0K
Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications
08:50

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

7.3K

Area of Science:

  • Biomaterials Science
  • Supramolecular Chemistry
  • Cell Biology

Background:

  • G-quartet structures are unique nucleic acid structures with potential in biomaterials.
  • Hydrogels offer versatile scaffolds for biological applications.
  • Developing stable and functional hydrogels is crucial for tissue engineering and drug delivery.

Purpose of the Study:

  • To synthesize and characterize novel G-quartet hydrogels using natural guanosine.
  • To investigate the ability of these hydrogels to support cell growth.
  • To assess the stability and degradation properties of the functional hydrogels.

Main Methods:

  • G-quartet hydrogels were formed by cross-linking natural guanosine with benzene-1,4-diboronic acid.
  • Magnesium ions (Mg2+) were used as a key component in the hydrogel formation.
  • Cell culture experiments were performed on the synthesized hydrogels to evaluate cell viability and growth.
  • Gel degradation was monitored visually and potentially through other analytical techniques.

Main Results:

  • Successfully formed functional G-quartet hydrogels from natural guanosine, benzene-1,4-diboronic acid, and Mg2+.
  • The hydrogels demonstrated the ability to support cell growth effectively.
  • No visible signs of hydrogel degradation were observed during the study period, indicating excellent stability.

Conclusions:

  • The developed G-quartet hydrogels are stable and functional biomaterials.
  • These hydrogels show significant potential for applications in cell culture, tissue engineering, and regenerative medicine.
  • The use of natural guanosine and simple cross-linking agents offers a promising route for creating advanced hydrogel scaffolds.