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Dynamic thiol/disulphide homeostasis and its prognostic value in patients with non-ST elevation-acute coronary

Serkan Sivri1, Hacı Ahmet Kasapkara, Melike Polat

  • 1Department of Cardiology, Ahi Evran University Training and Research Hospital, Turkey. drserkansivri@gmail.com.

Kardiologia Polska
|November 14, 2017
PubMed

Insights

Dynamic thiol/disulphide homeostasis is altered in patients with non-ST elevation acute coronary syndromes (NSTE-ACS). These thiol/disulphide homeostasis parameters may help predict prognosis in NSTE-ACS patients.

Area of Science:

  • Biochemistry
  • Cardiology
  • Oxidative Stress

Background:

  • Cardiovascular diseases remain a leading cause of death globally.
  • Oxidative stress is a key factor in the development of acute coronary syndromes (ACS).
  • Dynamic thiol/disulphide homeostasis is crucial for maintaining the balance between oxidants and antioxidants.

Purpose of the Study:

  • To investigate the relationship between dynamic thiol/disulphide homeostasis parameters and non-ST elevation ACS (NSTE-ACS).

Main Methods:

  • A study involving 210 patients with NSTE-ACS and 185 controls.
  • Evaluation of prognosis using the GRACE risk score and major adverse cardiovascular event (MACE) development.

Main Results:

  • Lower levels of native thiol, total thiol, and altered thiol/disulphide ratios were observed in the NSTE-ACS group.
  • Significant differences in thiol levels were noted across GRACE risk score subgroups.
  • A correlation was found between MACE and native thiol levels.

Conclusions:

  • Dynamic thiol/disulphide homeostasis parameters show significant differences in NSTE-ACS patients.
  • These parameters show potential for predicting prognosis in individuals with NSTE-ACS.
Abstract

Keywords:
GRACE risk scoredynamic thiol/disulphide homeostasismajor adverse cardiovascular eventnon-ST elevation acute coronary syndromeoxidative stress

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