Related Experiment Video
Updated: Feb 18, 2026
Formation of Human Periodontal Ligament Cell Spheroids on Chitosan Films
Published on: June 19, 2019
Engineered scaffolds and cell-based therapy for periodontal regeneration
Daniela Carmagnola1, Mihai Tarce2, Claudia Dellavia1
1Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi Milano, Milan - Italy.
Background:
The main objective of regenerative periodontal therapy is to completely restore the periodontal tissues lost. This review summarizes the most recent evidence in support of scaffold- and cell-based tissue engineering, which are expected to play a relevant role in next-generation periodontal regenerative therapy.
Methods:
A literature search (PubMed database) was performed to analyze more recently updated articles regarding periodontal regeneration, scaffolds and cell-based technologies.
Results:
Evidence supports the importance of scaffold physical cues to promote periodontal regeneration, including scaffold multicompartmentalization and micropatterning. The in situ delivery of biological mediators and/or cell populations, both stem cells and already differentiated cells, has shown promising in vivo efficacy.
Conclusions:
Porous scaffolds are pivotal for clot stabilization, wound compartmentalization, cell homing and cell nutrients delivery. Given the revolutionary introduction of rapid prototyping technique and cell-based therapies, the fabrication of custom-made scaffolds is not far from being achieved.
More Related Videos
09:35Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
Published on: September 11, 2015
05:20Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications
Published on: May 31, 2018