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Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Published on: August 23, 2016

Zika virus: what we need to know?

Farakh Javed¹, Khanzadi N Manzoor¹, Mubashar Ali¹

¹Department of Microbiology, University of Haripur, Haripur, Pakistan.

Journal of Basic Microbiology

|November 14, 2017

Summary

Zika virus (ZIKV) is an emerging mosquito-borne threat. This review covers ZIKV epidemiology, transmission, diagnosis, and potential treatments, highlighting knowledge gaps.

Keywords:

Aedes aegypti Zika virus genetic variability non-structural proteins

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Area of Science:

Virology
Epidemiology
Public Health

Background:

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus posing a global health threat.
Transmission primarily occurs via Aedes aegypti mosquitoes, with outbreaks reported globally.
ZIKV infection can range from asymptomatic to severe, with no specific antiviral treatments available.

Purpose of the Study:

To review current knowledge on Zika virus (ZIKV) epidemiology and transmission.
To discuss ZIKV structural biology, diagnosis, and associated challenges.
To highlight potential antiviral drugs and vaccines for ZIKV treatment.

Main Methods:

Literature review of ZIKV research.
Analysis of epidemiological data and outbreak reports.
Synthesis of information on ZIKV transmission, genetics, and clinical aspects.

Main Results:

ZIKV outbreaks have increased globally, necessitating greater attention.
Aedes aegypti is the primary vector, with rapid virus dissemination.
Significant knowledge gaps exist regarding ZIKV transmission, pathogenicity, and genomic structure.

Conclusions:

Further research is crucial to understand ZIKV transmission and pathogenicity.
Development of effective diagnostics, antivirals, and vaccines is urgently needed.
Enhanced surveillance and public health strategies are vital to control ZIKV spread.