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Updated: Feb 18, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Diagnosis of Kawasaki disease
Surjit Singh1, Ankur Kumar Jindal1, Rakesh Kumar Pilania1
1Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Post-Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Insights
Kawasaki disease (KD), a vasculitis affecting coronary arteries, is diagnosed clinically. Echocardiography aids in diagnosing and managing KD, particularly in challenging pediatric cases.
Area of Science:
- Pediatric Rheumatology
- Cardiovascular Medicine
- Vasculitis Research
Background:
- Kawasaki disease (KD) is a primary cause of acquired heart disease in children.
- Diagnosis relies on clinical criteria due to the absence of a specific laboratory test.
- Atypical and incomplete presentations complicate KD diagnosis, especially in infants.
Purpose of the Study:
- To review diagnostic steps for Kawasaki disease.
- To emphasize the role of echocardiography in KD diagnosis and management.
- To provide an overview of current diagnostic guidelines.
Main Methods:
- Literature review of Kawasaki disease diagnosis and management.
- Analysis of clinical criteria and diagnostic challenges.
- Discussion of echocardiographic findings in KD.
Main Results:
- Current diagnostic criteria, including the 2017 AHA guidelines, are presented.
- Challenges in diagnosing incomplete or atypical KD are highlighted.
- Echocardiography is crucial for identifying coronary artery abnormalities.
Conclusions:
- Accurate diagnosis of Kawasaki disease requires careful clinical evaluation.
- Echocardiography is essential for timely diagnosis and effective management of KD.
- Further research may improve diagnostic accuracy for atypical KD presentations.
Abstract:
Kawasaki disease (KD) is a medium vessel vasculitis with predilection for coronary arteries. Due to lack of a reliable confirmatory laboratory test, the diagnosis of KD is based on a constellation of clinical findings that appear in a typical temporal sequence. These diagnostic criteria have been modified from time to time and the most recent guidelines have been proposed by the American Heart Association (AHA) in 2017. However, several children may have incomplete or atypical forms of KD and the diagnosis can often be difficult, especially in infants and young children. In this review, we have detailed the steps involved in arriving at a diagnosis of KD and also highlight the important role of echocardiography in diagnosis and management of children with KD.
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