Related Experiment Video
Updated: Feb 18, 2026
Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
Published on: April 2, 2021
Insights
Retinopathy of prematurity (ROP) is a serious eye condition in premature infants. Recent advancements include predictive screening algorithms, anti-VEGF treatments, and advanced retinal imaging for better ROP management.
Area of Science:
- Ophthalmology
- Neonatology
- Pediatric Medicine
Background:
- Retinopathy of prematurity (ROP) involves abnormal retinal blood vessel growth in premature infants.
- It results from fluctuating oxygen levels (hyperoxia followed by hypoxia).
- ROP can lead to severe visual impairment, including blindness.
Purpose of the Study:
- To review current significant topics in retinopathy of prematurity.
- To discuss evolving global incidence, predictive screening tools, and novel treatments.
Main Methods:
- Review of recent literature on retinopathy of prematurity.
- Focus on key areas: changing incidence, predictive algorithms, anti-VEGF therapies, and advanced imaging.
Main Results:
- Global incidence of ROP is changing.
- Predictive algorithms show promise for ROP screening.
- Anti-vascular endothelial growth factor (anti-VEGF) treatments demonstrate emerging efficacy.
- Advanced retinal imaging aids in monitoring premature infants.
Conclusions:
- Ongoing research is crucial for understanding and managing ROP.
- New screening and treatment modalities are improving ROP care.
- Advanced imaging offers new insights into ROP progression.
Abstract:
Retinopathy of prematurity (ROP) is a condition seen in premature infants that is characterized by abnormal retinal blood vessel growth incited by relative hyperoxia and followed by hypoxia. It can have severe consequences ranging from high myopia to blindness. This article reviews recent "hot" topics related to ROP, specifically the changing incidence of ROP worldwide, the advent of predictive algorithms for screening for ROP, the emerging data behind efficacy of anti-vascular endothelial growth factor treatments for ROP, and advanced retinal imaging in children who were born premature. [Pediatr Ann. 2017;46(11):e415-e422.].
