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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
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Related Experiment Video

Updated: Feb 18, 2026

Paw-Print Analysis of Contrast-Enhanced Recordings PrAnCER: A Low-Cost, Open-Access Automated Gait Analysis System for Assessing Motor Deficits
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Capgras Syndrome in Advanced Parkinson's Disease.

Christopher L Groth1, Antonia Pusso1, Scott A Sperling1

  • 1From the Department of Neurology, University of Virginia, Charlottesville, Va. (CLG, SAS, GFW, MJB); the School of Medicine, University of Virginia, Charlottesville, Va. (AP); the Department of Physical Therapy, University of Virginia, Charlottesville, Va. (DSH); and the Department of Neurosurgery, University of Virginia, Charlottesville, Va. (WJE).

The Journal of Neuropsychiatry and Clinical Neurosciences
|November 15, 2017
PubMed
Summary

Psychosis, including uncommon Capgras syndrome, can occur in Parkinson's disease patients after deep brain stimulation (DBS). However, DBS does not appear to cause Capgras syndrome, though screening for psychosis is recommended.

Area of Science:

  • Neurology
  • Neuroscience
  • Psychiatry

Background:

  • Psychosis is a frequent complication in advanced Parkinson's disease (PD).
  • Capgras syndrome (CS) is an uncommon delusional misidentification syndrome.
Keywords:
Parkinson-s DiseasePsychosis

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  • Deep brain stimulation (DBS) is a treatment option for advanced PD.