Related Experiment Video
Updated: Feb 18, 2026

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
Published on: May 31, 2021
Know thy eHealth user: Development of biopsychosocial personas from a study of older adults with heart failure
Richard J Holden1, Anand Kulanthaivel2, Saptarshi Purkayastha2
1Department of BioHealth Informatics, Indiana University School of Informatics and Computing, Indianapolis, IN, USA; Indiana University Center for Aging Research (IUCAR), Regenstrief Institute, Inc., Indianapolis, IN, USA.
Background:
Personas are a canonical user-centered design method increasingly used in health informatics research. Personas-empirically-derived user archetypes-can be used by eHealth designers to gain a robust understanding of their target end users such as patients.
Objective:
To develop biopsychosocial personas of older patients with heart failure using quantitative analysis of survey data.
Method:
Data were collected using standardized surveys and medical record abstraction from 32 older adults with heart failure recently hospitalized for acute heart failure exacerbation. Hierarchical cluster analysis was performed on a final dataset of n=30. Nonparametric analyses were used to identify differences between clusters on 30 clustering variables and seven outcome variables.
Results:
Six clusters were produced, ranging in size from two to eight patients per cluster. Clusters differed significantly on these biopsychosocial domains and subdomains: demographics (age, sex); medical status (comorbid diabetes); functional status (exhaustion, household work ability, hygiene care ability, physical ability); psychological status (depression, health literacy, numeracy); technology (Internet availability); healthcare system (visit by home healthcare, trust in providers); social context (informal caregiver support, cohabitation, marital status); and economic context (employment status). Tabular and narrative persona descriptions provide an easy reference guide for informatics designers.
Discussion:
Personas development using approaches such as clustering of structured survey data is an important tool for health informatics professionals. We describe insights from our study of patients with heart failure, then recommend a generic ten-step personas development process. Methods strengths and limitations of the study and of personas development generally are discussed.
Related Concept Videos
Erikson's Theory on Socioemotional Development during Adulthood
Intimacy Versus Isolation in Early Adulthood
Individuals in early...
Heart Failure II: Pathophysiology
Pathophysiology of Heart Failure
Pharmacodynamics in Geriatric Patients: Effects of Age
Heart Failure III: Clinical Manifestations
Heart Failure I: Introduction

