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Published on: January 26, 2016
Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives
1Laboratoire de Chimie Bio-Organique, U.A. 488 du CNRS, Université des Sciences et Techniques du Languedoc, Montpellier, France.
Journal of Medicinal Chemistry
|February 1, 1989
Abstract:
Some N-(dipeptidyl)-S-acetylcysteamine and N,N'-(dipeptidyl)cystamine salt derivatives were synthesized and evaluated as candidate radioprotector agents. Toxicity and radioprotective activity as the dose reduction factor (DRF) were determined in vivo on mice and compared to N-glycyl-S-acetylcysteamine trifluoroacetate. One of the most interesting compounds of this series was N-glycylglycyl-S-acetylcysteamine trifluoroacetate (8).

