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Neurocognitive performance profile postparathyroidectomy: a pilot study of computerized assessment
Caitlin F Bell1, Mathew M Warrick1, Kathleen C Gallagher1
1Division of Surgical Oncology & Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN.
Surgery
|November 15, 2017
Summary
Primary hyperparathyroidism significantly impairs neurocognitive functions like memory and attention. Parathyroidectomy improves these deficits within six months, suggesting surgery benefits cognitive health.
Area of Science:
- Endocrinology
- Neuroscience
- Medical Diagnostics
Background:
- Primary hyperparathyroidism (PHPT) is associated with neurocognitive symptoms, but these deficits are not fully characterized.
- Understanding and assessing cognitive impairment in PHPT is crucial for diagnosis and management.
Purpose of the Study:
- To evaluate neurocognitive performance in patients with primary hyperparathyroidism before and after parathyroidectomy.
- To assess the efficacy of computerized neurocognitive testing in identifying and quantifying cognitive deficits in PHPT.
Main Methods:
- A prospective pilot study involved patients with confirmed primary hyperparathyroidism.
- Neurocognitive function was assessed using a computerized battery of tests (LUMOSITY) preoperatively and at 2 weeks and 6 months post-parathyroidectomy.
- Statistical analysis included univariate analysis and repeated measures of ANOVA to compare patient performance with controls.
Main Results:
- Patients with primary hyperparathyroidism exhibited significant deficits in memory, attention, mental flexibility, and processing speed compared to controls.
- Overall neurocognitive performance scores were significantly lower preoperatively and at 2 weeks post-surgery.
- These cognitive deficits improved and were no longer significant by 6 months after parathyroidectomy.
Conclusions:
- Computerized neurocognitive assessment effectively demonstrated the cognitive benefits of parathyroidectomy in PHPT patients.
- Further research is needed to validate this method as a long-term, objective diagnostic and prognostic tool for PHPT-related cognitive dysfunction.
