Risks for comorbidity in children with atopic disorders: an observational study in Dutch general practices

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David H J Pols1, Arthur M Bohnen1, Mark M J Nielen2

  • 1Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

BMJ Open
|November 15, 2017
PubMed

Insights

Children with atopic disorders like eczema, asthma, and allergic rhinitis face higher risks for other related conditions. Early recognition of these comorbidities is crucial for effective treatment and improved quality of life.

Area of Science:

  • Pediatric Allergy and Immunology
  • Primary Care Medicine
  • Epidemiology

Background:

  • Atopic disorders, including atopic eczema, asthma, and allergic rhinitis, are common in children.
  • Comorbidities, both atopic and non-atopic, can significantly impact a child's health and quality of life.
  • Understanding the spectrum of associated conditions is vital for comprehensive patient management.

Purpose of the Study:

  • To investigate the range of atopic and non-atopic comorbid symptoms and diseases in children diagnosed with physician-diagnosed atopic disorders.
  • To identify specific comorbidity patterns associated with atopic eczema, asthma, and allergic rhinitis in pediatric populations.

Main Methods:

  • Utilized a nationwide primary care database from the Netherlands Institute for Health Services Research.
  • Included children aged 0-18 years with routinely collected healthcare data from 2014.
  • Employed logistic regression analysis to assess associations between atopic disorders and comorbid conditions, calculating odds ratios (ORs).

Main Results:

  • Children with one atopic disorder had an increased risk of other atopic-related symptoms, irrespective of formal diagnosis.
  • Atopic eczema was linked to increased risks of infectious skin diseases (OR: 1.2-3.4).
  • Asthma correlated with higher occurrences of airway symptoms/diseases (OR: 2.1-10.3), and allergic rhinitis with ENT issues (OR: 1.5-3.9).

Conclusions:

  • General practitioners may not always recognize the full scope of atopic and non-atopic comorbidities in children.
  • Children with existing atopic disorders require targeted attention for associated conditions to prevent under-treatment.
  • Proactive management of comorbidities is essential to improve health outcomes and quality of life for affected children.
Abstract

Keywords:
EpidemiologyPaediatricsPrimary Care

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