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Case-control study of men with suspected chronic idiopathic prostatitis
R E Berger1, J N Krieger, D Kessler
1Department of Urology, University of Washington School of Medicine, Seattle.
The Journal of Urology
|February 1, 1989
Summary
This study investigated infectious causes of chronic prostatitis in men. Researchers found no evidence of Chlamydia trachomatis or other significant infections, suggesting non-bacterial origins for the condition.
Area of Science:
- Urology
- Infectious Diseases
- Microbiology
Background:
- Chronic prostatitis is a common condition with often unclear etiology.
- Identifying infectious agents is crucial for effective treatment strategies.
Purpose of the Study:
- To investigate the prevalence of specific infectious agents in men with chronic prostatitis.
- To compare microbial findings and inflammatory markers between symptomatic and asymptomatic men.
Main Methods:
- Prospective study of 50 asymptomatic men and 34 men with chronic prostatitis symptoms.
- Cultures of urethral and prostatic secretions for Chlamydia trachomatis.
- 4-glass prostatic localization cultures for bacteria (Ureaplasma urealyticum, Mycoplasma hominis) and fungi.
- Prostatic fluid leukocyte counts.
Main Results:
- Symptomatic men showed significantly higher prostatic fluid leukocyte counts (11/27 vs 0/44).
- Ureaplasma urealyticum was detected at a higher concentration in prostatic secretions of controls compared to first voided urine (13/50 vs 0/30).
- Chlamydia trachomatis was not isolated from any participant; no other significant differences were found.
Conclusions:
- The study did not identify a specific infectious cause for chronic nonbacterial prostatitis in the studied population.
- Inflammation markers were elevated in symptomatic patients, but a clear infectious etiology was not established.