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Updated: Jan 6, 2026
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Availability and Use of Shared Data From Cardiometabolic Clinical Trials
Muthiah Vaduganathan1, Amulya Nagarur2, Arman Qamar3
1Brigham and Women's Hospital Heart & Vascular Center and Harvard Medical School, Boston, MA (M.V., A.Q., D.L.B.). mvaduganathan@bwh.harvard.edu.
Circulation
|November 15, 2017
Summary
Patient-level data sharing for cardiometabolic trials is available, but underutilized. Few trials have been accessed, and even fewer analyses have led to publications, despite widespread endorsement of data sharing.
Area of Science:
- Cardiology
- Endocrinology
- Clinical Pharmacology
Background:
- Patient-level clinical trial data sharing is widely supported.
- Limited information exists on the utilization of shared data in cardiometabolic diseases.
Purpose of the Study:
- To assess the availability and use of shared patient-level data from clinical trials focused on cardiometabolic diseases.
Main Methods:
- Data were extracted from ClinicalStudyDataRequest.com, a platform with data from 13 pharmaceutical companies.
- Included trials evaluated cardiometabolic therapeutics, covering 74 therapies and 398,925 patients.
Main Results:
- Of 537 cardiometabolic trials (16% of total), 79 (29% of phase 3/4) had data access requests.
- Most data requesters were academic, and proposals focused on secondary hypotheses.
- Only 3 peer-reviewed articles were published from these shared data.
Conclusions:
- Despite data availability from over 500 trials, access and publication rates remain low.
- A small fraction of cardiometabolic trials and phase 3/4 trials have been accessed by researchers.
- The publication output from shared cardiometabolic clinical trial data is currently negligible.
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