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Predescemetocele: A distinct clinical entity.

Priya Narang1, Amar Agarwal2, Dhivya Ashok Kumar2

  • 1Narang Eye Care and Laser Centre, Ahmedabad, Gujarat, India.

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|November 15, 2017
PubMed
Summary
This summary is machine-generated.

Fourier-domain optical coherence tomography (OCT) confirms the pre-Descemet's layer (PDL) overlying a descemetocele, establishing predescemetocele as a distinct clinical entity. PDL presence indicates resilience and influences surgical treatment options for descemetocele.

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Anatomical Pathology

Background:

  • A descemetocele represents a significant corneal pathology where Descemet's membrane is exposed.
  • The clinical significance and anatomical characteristics of a pre-Descemet's layer (PDL) overlying a descemetocele require further elucidation.

Observation:

  • Fourier-domain optical coherence tomography (OCT) visualized the pre-Descemet's layer (PDL; Dua's layer) in two cases of descemetocele.
  • OCT demonstrated PDL as an intact layer covering an unruptured descemetocele.

Findings:

  • The presence of PDL over a descemetocele defines a distinct clinical entity, termed predescemetocele.
  • The PDL provides resilience to the descemetocele, potentially altering its management.
  • Loss of PDL precedes Descemet's membrane exposure and rupture.

Implications:

  • Predescemetocele should be recognized as a separate clinical entity from a simple descemetocele.
  • The presence of PDL may guide surgical decisions, favoring elective deep anterior lamellar keratoplasty or penetrating keratoplasty.
  • Understanding PDL's role is crucial for predicting descemetocele rupture risk.