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Methoxsalen-induced macular toxicity.

Aditya Maitray¹, Pukhraj Rishi¹

¹Shri Bhagwan Mahavir Department of Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Indian Journal of Ophthalmology

|November 15, 2017

Summary

This summary is machine-generated.

Methoxsalen, used for vitiligo, can cause vision loss. This case highlights potential posterior segment ocular toxicity, emphasizing the need for eye protection during treatment.

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Area of Science:

Ophthalmology
Dermatology
Photobiology

Background:

Methoxsalen and ultraviolet A (UVA) therapy (PUVA) treats skin disorders like psoriasis and vitiligo.
Methoxsalen is a photosensitizer, increasing skin sensitivity to UV light.
Oral methoxsalen is linked to premature cataracts due to protein adducts in the lens.

Observation:

UV-filtering glasses are recommended during PUVA therapy to prevent ocular exposure.
Ocular tissues may be exposed to methoxsalen's photosensitizing effects from incidental sunlight.
This can potentially lead to macular toxicity if protective eyewear is not used.

Findings:

This report details a case of bilateral macular toxicity in a middle-aged male patient.
The patient was undergoing methoxsalen treatment for vitiligo.
This represents a previously unreported posterior segment ocular toxicity associated with methoxsalen.

Implications:

Findings suggest a risk of posterior segment ocular toxicity from methoxsalen, beyond known cataract risks.
Reinforces the critical importance of consistent UV-protective eyewear use during and after methoxsalen therapy.
Highlights the need for further research into methoxsalen's ocular side effects and patient monitoring protocols.