Related Experiment Video

Updated: Feb 18, 2026

RhoC GTPase Activation Assay
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RhoC GTPase Activation Assay

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The Rho GTPase signalling pathway in urothelial carcinoma

Solomon L Woldu1, Ryan C Hutchinson1, Laura-Maria Krabbe1

  • 1University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9110, USA.

Nature Reviews. Urology
|November 15, 2017
PubMed

Insights

Urothelial carcinoma poses treatment challenges. Rho GTPase signaling pathways are implicated in this cancer and may offer future therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Urothelial carcinoma presents significant clinical challenges, with high recurrence rates for non-muscle-invasive disease and poor outcomes for advanced stages due to limited systemic therapies.
  • The Rho GTPase family, comprising over 20 enzymes, plays crucial roles in fundamental cellular processes like migration, polarity, adhesion, cell cycle, and cytoskeleton regulation.

Purpose of the Study:

  • To explore the role of Rho GTPase signaling pathways in urothelial carcinoma.
  • To investigate the potential of targeting Rho GTPase pathways for therapeutic intervention in urothelial carcinoma.

Main Methods:

  • Review of existing literature on Rho GTPase function and their implication in malignancies.
  • Analysis of the current understanding of Rho GTPase aberrations in urothelial carcinoma.

Main Results:

  • Rho GTPases function as molecular switches, cycling between inactive (GDP-bound) and active (GTP-bound) states.
  • Aberrations in Rho GTPase signaling pathways are increasingly linked to various cancers, including urothelial carcinoma.

Conclusions:

  • The Rho GTPase signaling pathway is a promising area for therapeutic targeting in urothelial carcinoma.
  • Current research is in its early stages, requiring further investigation to translate laboratory findings into clinical applications.

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