Research advances in kinase enzymes and inhibitors for cardiovascular disease treatment
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Updated: Feb 18, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
Published on: December 7, 2014
Rand Shahin1,1, Omar Shaheen2,2, Faris El-Dahiyat3,3
1Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Hashemite University, Az-Zarqa, Jordan.
Abstract:
The targeting of protein kinases has great future potential for the design of new drugs against cardiovascular diseases (CVDs). Enormous efforts have been made toward achieving this aim. Unfortunately, kinase inhibitors designed to treat CVDs have suffered from numerous limitations such as poor selectivity, bad permeability and toxicity. So, where are we now in terms of discovering effective kinase targeting drugs to treat CVDs? Various drug design techniques have been approached for this purpose since the discovery of the inhibitory activity of Staurosporine against protein kinase C in 1986. This review aims to provide context for the status of several emerging classes of direct kinase modulators to treat CVDs and discuss challenges that are preventing scientists from finding new kinase drugs to treat heart disease.
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