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Infiltrative Intraocular Conjunctival Squamous Cell Carcinoma after Local Resection and Brachytherapy: Clinical and
Magnolia Trinidad Cano-Suárez1,2, María Antonia Saornil-Álvarez1,2, Ciro García-Álvarez1,2
1Department of Ophthalmology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Ocular Oncology and Pathology
|November 15, 2017
Summary
This case report details a rare intraocular diffuse recurrence of conjunctival squamous cell carcinoma (CSCC) following surgery and brachytherapy. It highlights the importance of monitoring for ocular invasion after initial treatment.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Conjunctival squamous cell carcinoma (CSCC) is a malignant epithelial tumor of the ocular surface.
- While typically treated with resection and adjuvant therapy, rare cases of recurrence and intraocular invasion can occur.
Purpose of the Study:
- To report the first documented case of intraocular diffuse recurrence of CSCC.
- To correlate clinical findings with histopathologic evidence of tumor invasion and radiation effects.
Main Methods:
- Case presentation of a 70-year-old pseudophakic male with recurrent CSCC.
- Surgical excision, adjuvant brachytherapy, and subsequent enucleation.
- Detailed histopathologic examination of the enucleated eye.
Main Results:
- Initial diagnosis of well-differentiated CSCC with positive margins.
- Development of anterior chamber seeding and corneal perforation post-brachytherapy.
- Histopathology confirmed scleral infiltration and corneal invasion by squamous carcinoma cells.
Conclusions:
- This case represents the first documented intraocular diffuse recurrence of CSCC after resection and adjuvant brachytherapy.
- The findings underscore the aggressive potential of CSCC and the need for vigilant follow-up.
- Clinicopathologic correlation revealed radiation effects alongside tumor invasion in ocular tissues.
