Related Experiment Video

Updated: Aug 18, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

Chemotherapeutic management of epidural neuroblastoma

F A Hayes1, A A Green, D M O'Connor

  • 1Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105.

Medical and Pediatric Oncology
|January 1, 1989
PubMed

Insights

Chemotherapy induction for neuroblastoma with spinal cord compression in children can achieve excellent neurological outcomes. This approach, avoiding laminectomy and radiotherapy, shows promise for managing epidural neuroblastoma extension.

Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Neurosurgery

Background:

  • Neuroblastoma is a common pediatric cancer.
  • Spinal cord compression is a serious complication of neuroblastoma.
  • Current management often involves surgery and radiotherapy.

Purpose of the Study:

  • To evaluate the efficacy of initial chemotherapy induction for neuroblastoma with spinal cord compression.
  • To assess neurological outcomes in children treated with this conservative approach.

Main Methods:

  • Nine children with neuroblastoma and spinal cord compression were treated with chemotherapy induction.
  • Laminectomy and radiotherapy were not used as initial management.

Main Results:

  • Seven of nine children achieved normal neurological function.
  • One child had minimal residual neurological deficits.
  • One child remained paraplegic.

Conclusions:

  • Initial chemotherapy induction is a valid and effective approach for pediatric neuroblastoma with spinal cord compression.
  • This method can lead to excellent neurological recovery, avoiding more invasive treatments.

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Patient-Specific Electric Field Simulation In Spinal Metastasis Electrochemotherapy11:48

Patient-Specific Electric Field Simulation In Spinal Metastasis Electrochemotherapy

Published on: July 31, 2026

Related Concept Videos

Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...