Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imaging a terahertz superfluid plasmon in a two-dimensional superconductor.

Nature·2026
Same author

Investigating the role of executive function in brain responses to infant crying among new parents.

Social cognitive and affective neuroscience·2026
Same author

Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation (LLPS) and its reversal by selective, potent and orally-available PDE11A4 small molecule inhibitors both <i>in vitro</i> and <i>in vivo</i>.

bioRxiv : the preprint server for biology·2025
Same author

Current-driven nonequilibrium electrodynamics in graphene revealed by nano-infrared imaging.

Nature communications·2025
Same author

Intrinsic High-Fidelity Spin Polarization of Charged Vacancies in Hexagonal Boron Nitride.

Physical review letters·2025
Same author

Accelerating TB regimen development: introducing FAST-TB.

IJTLD open·2024

Related Experiment Video

Updated: Feb 18, 2026

A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration
09:24

A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration

Published on: March 10, 2023

2.5K

Retinal Structure in Pre-Clinical Age-Related Macular Degeneration.

S Nusinowitz1, Y Wang1, P Kim1

  • 1a Department of Ophthalmology , David Geffen School of Medicine-UCLA, Stein Eye Institute , Los Angeles , CA , USA.

Current Eye Research
|November 15, 2017
PubMed
Summary
This summary is machine-generated.

No consistent retinal structural changes were found in individuals with age-related macular degeneration (AMD) genetic risk. Retinal thickness varied slightly in early and intermediate AMD, but overall structure was not linked to genetic predisposition or aging.

Keywords:
AMDAge-related macular degenerationOCTretinastructure

More Related Videos

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

4.3K
Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow
08:54

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Published on: May 26, 2023

2.2K

Related Experiment Videos

Last Updated: Feb 18, 2026

A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration
09:24

A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration

Published on: March 10, 2023

2.5K
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

4.3K
Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow
08:54

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Published on: May 26, 2023

2.2K

Area of Science:

  • Ophthalmology
  • Genetics
  • Medical Imaging

Background:

  • Age-related macular degeneration (AMD) is a leading cause of vision loss.
  • Genetic factors significantly contribute to AMD risk.
  • Identifying early structural changes can aid in predicting disease progression.

Purpose of the Study:

  • To investigate if genetic risk for AMD correlates with identifiable retinal structural alterations.
  • To assess retinal structural changes in individuals with a family history of AMD.

Main Methods:

  • Prospective study of 73 subjects aged 51.5 to 68.9 years with a family history of AMD.
  • Ophthalmic examination, disease staging, genetic testing, and optical coherence tomography (OCT) imaging.
  • Semi-automated retinal layer segmentation to analyze structural changes.

Main Results:

  • Retinal volume measures were not associated with AMD classification, genetic risk, or age.
  • Outer retina thickening was observed in the foveal region of the intermediate AMD group.
  • Retinal pigment epithelium (RPE) thickening occurred in early and intermediate AMD groups in the central retina.

Conclusions:

  • No consistent retinal structural changes were identified in relation to AMD genetic risk or aging in this cohort.
  • Minor localized thickening in the outer retina and RPE were noted in early to intermediate AMD stages.