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Transcriptome-wide association study of inflammatory biologic age.

Honghuang Lin1,2, Kathryn L Lunetta1,3, Qiang Zhao3

  • 1National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA 01702, USA.

Aging
|November 15, 2017
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Summary

Researchers identified 448 genes linked to inflammatory biologic age, a key aging mechanism. These findings offer potential targets for interventions to promote healthy aging and extend healthspan in older adults.

Keywords:
agingepidemiologygene expressioninflammation

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Area of Science:

  • Genomics
  • Aging Research
  • Inflammation Biology

Background:

  • Chronic low-grade inflammation is a core process in aging.
  • Biologic age estimation offers a molecular perspective on aging.
  • Understanding genetic links to inflammatory aging is crucial for healthspan research.

Purpose of the Study:

  • To estimate inflammatory biologic age using multiple biomarkers.
  • To identify genes associated with inflammatory biologic age.
  • To explore potential molecular targets for aging interventions.

Main Methods:

  • Utilized the Klemera-Doubal method to calculate inflammatory biologic age (∆Age).
  • Measured whole blood gene expression in 2386 participants from the Framingham Offspring Study.
  • Employed linear mixed-effects models to associate ∆Age with gene expression.

Main Results:

  • Identified 448 genes significantly associated with inflammatory ∆Age (P<2.8x10^-6).
  • 302 genes showed positive association, and 146 showed negative association.
  • Pathway analysis implicated NOD-like receptor signaling and ubiquitin-mediated proteolysis.

Conclusions:

  • 448 genes are significantly associated with inflammatory biologic age.
  • These genes may represent novel targets for interventions.
  • Further research could lead to strategies for delaying aging and enhancing healthspan.