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Chronic kidney disease incidence and survival of Thai HIV-infected patients

Wannarat Pongpirul1, Krit Pongpirul2,3, Jintanat Ananworanich4

  • 1Department of Medicine, Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand.

AIDS (London, England)
|November 15, 2017
PubMed

Insights

The incidence of chronic kidney disease (CKD) in Thai HIV patients on antiretroviral therapy is lower than in other populations. Key risk factors include age, HIV viral load, diabetes, and hypercholesterolemia.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Nephrology

Background:

  • Limited data exists on chronic kidney disease (CKD) incidence in Asian HIV patients.
  • Antiretroviral therapy (ART) is standard care for HIV infection.
  • Understanding CKD risk factors in this population is crucial for effective management.

Purpose of the Study:

  • To estimate the incidence of CKD in HIV-infected patients receiving standard ART in Thailand.
  • To compare demographic and clinical characteristics of patients who developed CKD versus those who did not.

Main Methods:

  • A multicenter, observational prospective cohort study was conducted.
  • CKD diagnosis followed KDIGO 2012 criteria using CKD-EPI eGFR with and without urine protein.
  • Kaplan-Meier estimation analyzed cumulative CKD incidence.

Main Results:

  • 5430 HIV patients were analyzed, with 229 incident CKD cases over 22,035 person-years.
  • The overall CKD incidence rate was 10.39 per 1000 person-years.
  • Increased age, HIV viral load, diabetes mellitus, and hypercholesterolemia were significant risk factors for CKD.

Conclusions:

  • CKD incidence in Thai HIV patients on ART is lower compared to white and non-Southeast Asian populations.
  • Age, HIV viral load, diabetes, and hypercholesterolemia are significant risk factors for CKD development.
  • These findings highlight the importance of managing comorbidities and viral load in HIV-infected individuals to prevent CKD.
Abstract

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